Seaman Juan Díaz de Solís, navigating in the name of Spain, was the first European to reach the Río de la Plata in 1516. His expedition was cut short when he was killed during an attack by the native Charrúa tribe in what is now Uruguay.
The city of Buenos Aires was first established as Ciudad de Nuestra Señora Santa María del Buen Ayre (literally "City of Our Lady Saint Mary of the Fair Winds") after Our Lady of Bonaria (Patron Saint of the capital of Sardinia, Cagliari) on 2 February 1536 by a Spanish expedition led by Pedro de Mendoza . The settlement founded by Mendoza was located in what is today the San Telmo district of Buenos Aires, south of the city center.
More attacks by the indigenous peoples forced the settlers away, and in 1541 the site was abandoned. A second (and permanent) settlement was established in 1580 by Juan de Garay, who arrived by sailing down the Paraná River from Asunción (now the capital of Paraguay). He dubbed the settlement "Santísima Trinidad" and its port became "Puerto de Santa María de los Buenos Aires."
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